Changes in circadian rhythm have recently been implicated in obesity, diabetes, and cancer. Using cutting edge tools that include organoids and murine knockout models, we are able to investigate the complex genetic networks involved in circadian rhythm and how they affect host health and microbiome structure.
Intestinal motility and dysbiosis
The development of the gut microbiome and intestinal motility and is an interdependent relationship ie. changes, like stasis and constipation, in intestinal motility lead to microbial dysbiosis in the gut. Our group aims to understand this interaction and create interventions to treat gastrointestinal dysmotility.
Organoids are organ models made of tissue cultured from the organ of interest and allow unprecedented exploration into the realm between in vitro and ex vivo. We are able to simulate the effect of circadian drivers, carcinogens, pathogenic and probiotic microbes; all within highly replicable organoids of varying genotypes.
Genetically Engineered Mouse Models
With an enormous variety of mouse models having different genetic background, it is a challenge to maintain and derive genetically useful variants to best answer important research questions. Using floxed genes of interest, we are able to preserve viable strains of interest to meet some of the most challenging research propositions.